HypoglycAemic, Phytochemical and other Properties of Allium cepa L.

In the view of the promising potential of hypoglycaemic plants, 19 plants indigenous to Sudan and of common use in Sudanese folk-medicine, were screened for their hypoglycaemic activity. Out of these Allium cepa L being the most active, safe and non toxic, available and affordable, hence it had been selected for further investigation. Allium cepa was subjected to chemical tests and chromatographic procedures for the detection of its active components present.  Conducted tests and procedures confirmed the presence of sulfur compounds.  Comparative chromatographic methods as thin layer chromatography and C–18 high performance liquid chromatography revealed that the aminoacid, cysteine (0.059%) occurs as a major  constituent found in Allium cepa.  Allium cepa alcoholic extract was found to possess its hypoglycemic effect (36.33 mg/dl – reduction of glycemia) through a synergestic action of its similar sulfur phytoconstituents present, since less activity was exhibited by each of it’s fractions (aqueous and organic) obtained when partioned with hexane. We can conclude that the integrated properties of the active medicinal products especially edible plants with their hypoglycaemic activity, make their use for the control and prevention of diabetes mellitus possible and recommendable.  Unstability, similarity in constituents and synergy of their activity give reasons for not to isolate individual compounds from onions and give credits to use them whole as a crude drug or a concentrated extract.  Furthermore, descriptive characters, chemical tests and chromatographic profiles obtained in this study could be used as measures to standardize red onion growing in Sudan.                   &nbsp

Multi-metric Geographic Routing for Vehicular Ad hoc Networks

Maintaining durable connectivity during data forwarding in Vehicular Ad hoc Networks has witnessed significant attention in the past few decades with the aim of supporting most modern applications of Intelligent Transportation Systems (ITS). Various techniques for next hop vehicle selection have been suggested in the literature. Most of these techniques are based on selection of next hop vehicles from fixed forwarding region with two or three metrics including speed, distance and direction, and avoid many other parameters of urban environments. In this context, this paper proposes a Multi-metric Geographic Routing (M-GEDIR) technique for next hop selection. It selects next hop vehicles from dynamic forwarding regions, and considers major parameters of urban environments including, received signal strength, future position of vehicles, and critical area vehicles at the border of transmission range, apart from speed, distance and direction. The performance of M-GEDIR is evaluated carrying out simulations on realistic vehicular traffic environments. In the comparative performance evaluation, analysis of results highlight the benefit of the proposed geographic routing as compared to the state-of-the-art routing protocols

Types and costs of medications returned by outpatients at a Malaysian teachinghHospital: a one-year cross-sectional study

Introduction: Medication wastage is attributable to various factors, including therapeutic failure, over-prescription, and poor compliance. Data regarding the cost and types of returned medications are essential to estimate the financial burden that can be reduced locally through targeted intervention. This study aimed to investigate the types and cost of medications returned by outpatients at a teaching hospital in Kuantan, Pahang. Materials and methods: This cross-sectional study collected data from the electronic medical record based on the list of returned medications at the outpatient pharmacy department at Sultan Ahmad Shah medical Centre (SASMEC) @IIUM between January and December 2021. All medications with SASMEC patients' label were included. The medications were classified according to the classification index based on the British National Formulary. The data were analysed using Microsoft Excel version 16.52. The cost associated with returned medications was calculated, referring to the latest cost price of the respective medications. Results: A total of 134 patients returned their medications in 2021 (mean ± SD age: 63 ± 13 years), with 52% females. The total quantities of returned medications were 11,054 units. These included pills, devices (inhalers, insulin pens), bottles, and plastic containers. The overall cost of these medications was Ringgit Malaysia (RM) 13,594.90 (mean per patient: RM 101.45). The highest number of returned medications was from the cardiovascular group (32.5%), followed by the endocrine group (26%) and musculoskeletal group (11.9%). The highest cost for returned medications was the endocrine group (49%), followed by the cardiovascular group (20%) and the musculoskeletal group (10%). Conclusion: Medications used for cardiovascular diseases were the most frequently returned at outpatient pharmacy, whereas those for endocrine diseases contributed to the highest cost. Future research could focus on identifying modifiable factors that can contribute to the sustainability of health resources by reducing the cost of returned medications

Knowledge and practices of medication usage, storage and disposal among outpatients in a Malaysian teaching hospital: a qualitative study

Introduction: Improper storage and disposal of medications can cause pollution in the environment. Developing effective interventions tailored to local practices is important to reduce pharmaceutical wastage. Little is known concerning how Malaysian outpatients use, store, and dispose medicines. This study aimed to explore the experiences, challenges, and reflections perceived by outpatients addressing these issues. Materials and methods: A qualitative methodology was adopted by using a semi-structured interview guide to explore patients’ experiences related to their knowledge and practices of medication usage, storage, and disposal. A total of 15 patients and five caregivers were recruited at a teaching hospital in Kuantan, Pahang, for in-depth interview sessions. Each interview was recorded, transcribed verbatim, and translated into English. Data were sorted and coded using NVivo Release 1.5.1 software and subjected to thematic analysis. Results: The following themes were identified from the interviews, which were 1) incomplete labelling and instructions 2) scepticism about returning unused medications 3) lack of knowledge with varying practices 4) role of pharmacists to improve patient’s medication literacy 5) lack of accessibility to return unused medications, 6) needs of educational programmes /campaigns 7) required information on medicine prices. Conclusion: Management of medication usage, storage, and disposal seems to be multifactorial. Therefore, it is important to develop contextual strategies and effective interventions to improve patients’ knowledge and practices regarding medication usage, storage, and disposal. Future research is needed to develop and test the intervention of these components to reduce pharmaceutical wastage in the environment through best practices at all levels

The global burden of cancer attributable to risk factors, 2010-19 : a systematic analysis for the Global Burden of Disease Study 2019

Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings Globally, in 2019, the risk factors included in this analysis accounted for 4.45 million (95% uncertainty interval 4.01-4.94) deaths and 105 million (95.0-116) DALYs for both sexes combined, representing 44.4% (41.3-48.4) of all cancer deaths and 42.0% (39.1-45.6) of all DALYs. There were 2.88 million (2.60-3.18) risk-attributable cancer deaths in males (50.6% [47.8-54.1] of all male cancer deaths) and 1.58 million (1.36-1.84) risk-attributable cancer deaths in females (36.3% [32.5-41.3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20.4% (12.6-28.4) and DALYs by 16.8% (8.8-25.0), with the greatest percentage increase in metabolic risks (34.7% [27.9-42.8] and 33.3% [25.8-42.0]). Interpretation The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.Peer reviewe

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis

Search for heavy resonances decaying to two Higgs bosons in final states containing four b quarks

A search is presented for narrow heavy resonances X decaying into pairs of Higgs bosons (H) in proton-proton collisions collected by the CMS experiment at the LHC at root s = 8 TeV. The data correspond to an integrated luminosity of 19.7 fb(-1). The search considers HH resonances with masses between 1 and 3 TeV, having final states of two b quark pairs. Each Higgs boson is produced with large momentum, and the hadronization products of the pair of b quarks can usually be reconstructed as single large jets. The background from multijet and t (t) over bar events is significantly reduced by applying requirements related to the flavor of the jet, its mass, and its substructure. The signal would be identified as a peak on top of the dijet invariant mass spectrum of the remaining background events. No evidence is observed for such a signal. Upper limits obtained at 95 confidence level for the product of the production cross section and branching fraction sigma(gg -> X) B(X -> HH -> b (b) over barb (b) over bar) range from 10 to 1.5 fb for the mass of X from 1.15 to 2.0 TeV, significantly extending previous searches. For a warped extra dimension theory with amass scale Lambda(R) = 1 TeV, the data exclude radion scalar masses between 1.15 and 1.55 TeV

Measurement of the Splitting Function in &ITpp &ITand Pb-Pb Collisions at root&ITsNN&IT=5.02 TeV

Data from heavy ion collisions suggest that the evolution of a parton shower is modified by interactions with the color charges in the dense partonic medium created in these collisions, but it is not known where in the shower evolution the modifications occur. The momentum ratio of the two leading partons, resolved as subjets, provides information about the parton shower evolution. This substructure observable, known as the splitting function, reflects the process of a parton splitting into two other partons and has been measured for jets with transverse momentum between 140 and 500 GeV, in pp and PbPb collisions at a center-of-mass energy of 5.02 TeV per nucleon pair. In central PbPb collisions, the splitting function indicates a more unbalanced momentum ratio, compared to peripheral PbPb and pp collisions.. The measurements are compared to various predictions from event generators and analytical calculations.Peer reviewe

Search for supersymmetry in events with one lepton and multiple jets in proton-proton collisions at root s=13 TeV

Peer reviewe